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Timing of primary surgery for cleft palate

Gamble C, Persson C, Willadsen E, Albery L, Andersen HS, Antoneli MZ et al, for the TOPS Study Group.

N Engl J Med 2023; 389:795-807.

Some 552 infants were randomized to surgery at six or twelve months. Poor speech and language scores at age five were more common after surgery at twelve months: 15 versus 8.9 per cent, P=0.04.

Comment: Really useful study done in adequately resourced hospitals.

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