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Single CT colonography versus three rounds of faecal immunochemical test for population-based screening of colorectal cancer (SAVE): a randomised controlled trial.

Sali L, Ventura L, Mascalchi M, Falchini M, Mallardi M, Carozzi F et al.

Lancet Gastro Hepatol 2022; 7: 1016-1023.

Some 15,000 people were randomized and invited. Attendance was lower for CT colonography (26.7 per cent versus 33.4 per cent who participated in all three faecal testing rounds). Although the detection rate was higher with CT colonography (5.2 versus 3.1 per cent, P=0.0002). Overall detection (referral to work-up) was higher after three rounds of faecal testing (7.5 versus 2.7 per cent, P<0.0001).

Comment. Interesting that compliance with screening may be more important than the accuracy of the test.

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