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Outcomes of a delirium prevention program in older persons after elective surgery. A stepped-wedge cluster randomized clinical trial.

Deeken F, Sanchez A, Rapp MA, Denkinger M, Brefka S, Spank J et al, for the PAWEL Study Group.
JAMA Surg 2022; 157: e216370.

A total of 1470 patents were randomly allocated to a prevention programme or standard care. Overall, the programme reduced the rate of postoperative delirium: 5.3 per cent versus 6.9 per cent in controls, P=0.047. It was ineffective after cardiac surgery.

Comment: Small effect only.

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