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Follow-up schedule for patients with sentinel node–negative cutaneous melanoma (The MELFO Study). An international phase III randomized clinical trial.


Moncrieff MD, Bastiaannet E, Underwood B, Francken AB, Garioch J, Damude S et al.

Ann Surg 2022; 276: e208-e216.

Some 388 patients were enrolled into a study comparing standard follow-up with a reduced frequency schedule. There was no difference in recurrence rates between the groups. Three quarters of patients in both groups found their recurrence by self-examination.

Comment: Routine follow-up may not help patients with melanoma; perhaps an approach teaching them self-examination would be better.

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