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Efficacy and safety of adalimumab in conjunction with surgery in moderate to severe hidradenitis suppurativa. The SHARPS randomized clinical trial.

Bechara FG, Podda M, Prens EP, Horvath B, Giamarellos-Bourboulis EJ, Alavi A et al.
JAMA Surg 2021; 156: 1001-1009.

The effect of perioperative adalimumab continued for ten weeks after radical surgery (wide excision followed by secondary intention healing) was examined in this study that included 206 patients. A good clinical response was more common with adalimumab therapy: 48 versus 34 per cent, P=0.049.

Comment: Some possible hope for patients with a difficult disease to manage.

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