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Effects of a pragmatic home-based exercise program concurrent with neoadjuvant therapy on physical function of patients with pancreatic cancer. The PancFit randomized clinical trial.

Ngo-Huang AT, Parker NH, Xiao L, Schadler KL, Petzel MQB, Prakash L et al.

Ann Surg 2023; 278: 22-30.

Some 151 patients were included and all were given nutrition counselling and activity meters. Patients were randomized to additional aerobic and anaerobic resistance exercise during neoadjuvant chemotherapy. Six-minute walking distance was improved in both groups: 18.6 m in the usual care group and 27.3 m and those randomized to exercise. Clinical outcomes were similar.

Comment: No proof of any advantage for additional exercise.

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