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Early and empirical high-dose cryoprecipitate for hemorrhage after traumatic injury. The CRYOSTAT-2 randomized clinical trial.

Davenport R, Curry N, Fox EE, Thomas H, Lucas J, Evans A et all, for the CRYOSTAT-2 Principal Investigators.

This multicentre study included 1604 seriously injured patients with bleeding. Treatment with cryoprecipitate did not reduce the 30-day mortality rate: 25.3 per cent versus 26.1 per cent in controls (odds ratio 0.96, 95 per cent confidence interval 0.75 to 1.23, P=0.74).

Comment: Disappointing result.

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