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Dose-escalated simultaneous integrated boost radiotherapy in early breast cancer (IMPORT HIGH): a multicentre, phase 3, non-inferiority, open-label, randomised controlled trial.


Coles CE, Haviland JS, Kirby AM, Griffin CL, Sydenham MA, Titley JC et al, on behalf of the IMPORT Trial Management Group.

Lancet 2023; 401: 2124-2137.

A total of 2617 women were enrolled in the trial. Concomitant booster irradiation was safe, with similar rates of local recurrence: 2 per cent and 3.2 per cent in the different dosages, compared to 1.9 per cent in controls. Simultaneous booster irradiation reduced patient visits.

Comment: Easier for the women, and should improve treatment scheduling.

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