Join BJS Academy
BJS Academy>Randomized clinical ...>Bariatric–met...
Normal View Dyslexic View

Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trial

19 July 2023
Randomized clinical trials HPB
Verrastro O, Panunzi S, Castagneto-Gissey L, De Gaetano A, Lembo E, Capristo E et al.

Lancet 2023; 401: 1786-1797.

A total of 288 patients were randomly allocated to best medical therapy or one of two bariatric procedures. Stereohepatitis resolved in 70  per cent of patients who had either Roux-en-Y gastric bypass or sleeve gastrectomy compared to 19 per cent in the best medical treatment group; P<0.0001.

Comment: This study shows convincing evidence that non-alcoholic fatty liver can be reversed by bariatric surgery. Is that alone a reasonable indication?

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct104
Randomized clinical trials
Randomized clinical trials
HPB
Bariatric–metabolic surgery versus lifestyle intervention plus best medical care in non-alcoholic steatohepatitis (BRAVES): a multicentre, open-label, randomised trial
Verrastro O, Panunzi S, Castagneto-Gissey L, De Gaetano A, Lembo E, Capristo E et al.
19072023
Lancet 2023; 401: 1786-1797.
A total of 288 patients were randomly allocated to best medical therapy or one of two bariatric procedures. Stereohepatitis resolved in 70  per cent of patients who had either Roux-en-Y gastric bypass or sleeve gastrectomy compared to 19 per cent in the best medical treatment group; P<0.0001.
Comment: This study shows convincing evidence that non-alcoholic fatty liver can be reversed by bariatric surgery. Is that alone a reasonable indication?
Published on: 19 July 2023
Article ID: rct104

Related articles

Temporary portocaval shunt provides superior intraoperative hemodynamics and reduces blood loss and duration of surgery in live donor liver transplantation. A randomized controlled trial.

Kumar M, Patil NS, Mohapatra N, Sindwani G, Dhingra U, Yadav A et al.
Ann Surg 2024; 279: 932-944.

16 August 2024

Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial.

Bang JY, Lakhtakia S, Thakkar S, Buxbaum JL, Waxman I, Sutton B et al, on behalf of the United States Pancreatic Disease Study Group.

16 August 2024

Neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer (NORPACT-1): a multicentre, randomised, phase 2 trial.

Labori KJ, Bratlie SO, Andersson B, Angelsen J-H, Biorserud C, Bjornsson B et al, for the Nordic Pancreatic Cancer Trial-1 study group.

30 August 2024
Home
  • Normal view
  • Dyslexic view
Info
Copied!