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Antiseptic skin agents to prevent surgical site infection after incisional surgery. A randomized, three-armed combined non-inferiority and superiority clinical trial (NEWSkin prep study).

28 July 2022
Randomized clinical trials General
Smith S, Ridley S, Gani, J, Carroll, R, Lott, N, Hampton, et al.

Ann Surg 2022; 275: 842-848.

In this study that included 3123 procedures, surgical site infection rates were similar with all skin preparations: povidone iodine with alcohol 10.9 per cent; chlorhexidine with alcohol 11.1 per cent;  aqueous povidone iodine 12.6 per cent. There were no adverse events or differences in secondary outcomes.

Comment: This challenges the perceived benefits of alcoholic skin preparation.

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rct205
Randomized clinical trials
Randomized clinical trials
General
Antiseptic skin agents to prevent surgical site infection after incisional surgery. A randomized, three-armed combined non-inferiority and superiority clinical trial (NEWSkin prep study).
Smith S, Ridley S, Gani, J, Carroll, R, Lott, N, Hampton, et al.
28072022
Ann Surg 2022; 275: 842-848.
In this study that included 3123 procedures, surgical site infection rates were similar with all skin preparations: povidone iodine with alcohol 10.9 per cent; chlorhexidine with alcohol 11.1 per cent;  aqueous povidone iodine 12.6 per cent. There were no adverse events or differences in secondary outcomes.
Comment: This challenges the perceived benefits of alcoholic skin preparation.
Published on: 28 July 2022
Article ID: rct205

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