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Antibiotic prophylaxis in breast cancer surgery (PAUS trial): randomised clinical double-blind parallel-group multicentre superiority trial.

Stallard S, Savioli F, McConnachie A, Norrie J, Dudman K, Morrow ES et al.

Br J Surg 2022; 109: 1224–1231.

In this study that included 871 procedures, a single dose of Amoxicillin-clavulanic acid did not reduce the risk of wound infection up to 30 days: 16.2 per cent versus 19.2 per cent in controls, P=0.25.

Comment: not beneficial even in higher risk subgroups – obese or Staph aureus carriers.

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