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Aggressive or moderate fluid resuscitation in acute pancreatitis.

de-Madaria E, Buxbaum JL, Maisonneuve P, de Paredes AGG, Zapater P, Guilabert et al for the ERICA Consortium.

N Engl J Med 2022; 387: 989-1000.

This trial was stopped early after interim analysis of 249 patients. Aggressive fluid resuscitation resulted in a higher rate of fluid overload (20.5 versus 6.3 per cent, P=0.004), with no improvement in clinical outcomes.

Comment: Too much fluid.

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