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Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial

Nakachi K, Ikeda M, Konishi M, Nomura Skatayama H, Kataoka T, et al  on behalf of the Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG).

Lancet 2023; 401: 195-203.

In this study that included 440 procedures, after a median of 45.4 months, adjuvant S-1 therapy given for four cycles improved overall survival from 67.6 to 77.1 per cent, P=0.008.

Comment: A benchmark study for this rare condition, that provides a real hope of improved survival.

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