Join BJS Academy
BJS Academy>Randomized clinical ...>Adjuvant everolimus ...
Normal View Dyslexic View

Adjuvant everolimus after surgery for renal cell carcinoma (EVEREST): a double-blind, placebo-controlled, randomised, phase 3 trial.

6 December 2023
Randomized clinical trials General
Ryan CW, Tangen CM, Heath EI, Stein MN, Meng MV, Alva AS et al.

Lancet 2023; 402: 1043-1051.

Some 1545 patients were randomly assigned 10 mg of oral Everolimus daily or placebo for 54 weeks. 5-year recurrence-free survival was improved from 63 to 67 per cent (P=0.051), but this did not meet the prespecified P value for significance. Patients with more advanced disease benefitted most.

Comment: Not effective for most.

BJS Foundation Limited
BJS Academy
0000-0000
BJS Foundation Limited
London, UK
rct062
Randomized clinical trials
Randomized clinical trials
General
Adjuvant everolimus after surgery for renal cell carcinoma (EVEREST): a double-blind, placebo-controlled, randomised, phase 3 trial.
Ryan CW, Tangen CM, Heath EI, Stein MN, Meng MV, Alva AS et al.
06122023
Lancet 2023; 402: 1043-1051.
Some 1545 patients were randomly assigned 10 mg of oral Everolimus daily or placebo for 54 weeks. 5-year recurrence-free survival was improved from 63 to 67 per cent (P=0.051), but this did not meet the prespecified P value for significance. Patients with more advanced disease benefitted most.
Comment: Not effective for most.
Published on: 6 December 2023
Article ID: rct062

Related articles

Intrarenal pressure with hand-pump or pressurized-bag irrigation: randomized clinical trial at retrograde intrarenal surgery.

Croghan SM, O’Meara S, Cunnane EM, Purtill H, Walsh MT, O’Brien FJ et al.

7 August 2024

Efficacy and safety of bimekizumab in patients with moderate-to-severe hidradenitis suppurativa (BE HEARD I and BE HEARD II): two 48-week, randomised, double-blind, placebo-controlled, multicentre phase 3 trials.

Kimball AB, Jemec GBE, Sayed CJ, Kirby JS, Prens E, Ingram JR et al.

16 August 2024

Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy. A randomized clinical trial by CHIR-Net.

Mueller C, Kehl V, Dimpel R, Blankenstein C, Egert-Schwender SE, Strudthoff J, Lock JF et al, for the IOWISI Study Group.

16 August 2024
Home
  • Normal view
  • Dyslexic view
Info
Copied!