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Adjuvant everolimus after surgery for renal cell carcinoma (EVEREST): a double-blind, placebo-controlled, randomised, phase 3 trial.

Ryan CW, Tangen CM, Heath EI, Stein MN, Meng MV, Alva AS et al.

Lancet 2023; 402: 1043-1051.

Some 1545 patients were randomly assigned 10 mg of oral Everolimus daily or placebo for 54 weeks. 5-year recurrence-free survival was improved from 63 to 67 per cent (P=0.051), but this did not meet the prespecified P value for significance. Patients with more advanced disease benefitted most.

Comment: Not effective for most.

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